Question 421: It Had to be this way.

What does this map depict?
Carlisle and Newcastle shown here.

Question 420: Would Brett have Done That?

Logo.
Building.
Logo has name on it.
Building doesn't.
So, Identify the building, if possible,
But more importantly,

Explain the significance of the building.

Question 419: Pinky and the brain

Connect the following to a single theme

and provide an explanation for each picture.

Question 418; Beating round

This poem, published in richard poor's almanac ( a derivative of Franklin's poor richard's almanac no doubt) is a compendium, a compilation of what one would call comedy. In the past decade, we have heard these phrases individually, but the author took the liberty of compiling them into a poem

Question:
1 Id the person in question
2) The name of the poem(same as what has been blanked out)
3) The term it spawned

Question 417: Up up and away

THis describes the mechanism of what has been deemed as a miracle for mankind.

ID the blank

The mechanism of action of___X___ involves the protection of cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum. Nitric oxide (NO) in the corpus cavernosum of the _____ binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation (vasodilation) of the intimal cushions of the helicine arteries. This smooth muscle relaxation leads to vasodilation and increased inflow of blood into the spongy tissue, causing ________ . Robert F. Furchgott won the Nobel Prize in Physiology or Medicine in 1998 for his discovery and analysis of endothelium-derived relaxing factor or "EDRF", later identified with NO itself or a closely-related compound.

Question 416: tRick or treat

THis is from an extremely popular internet meme, im sure each one of us has been (pic2ed) many times.

Just id:
1) Character in pic 1
2) The blank in pic 2



pic 1


pic 2

Question 415: Grin and Beer it

In the beginning of the Obama administration, an incident occurred between a police officer X and a professor Y.
This caused Obama to call them both over for a beer at the white house
This is an XKCD parody of the event.

Question:
1) ID X and Y
2) What happened ( god is in the details,lol)

Question 414: At Ur Beck and Call

Yes, this post is most unlike me.
Science!
We've had enough of this in school, yeah?
Anyway,

What is this?
The title should give you a clue.

Question 413: And Bingo was his Name-o

Connect

Question 412: Time to nail it

This visual has often been used in Archies comics to denote any action or idea that seems to be quite aberrant to conventions. This phrase has its origins in a type of baseball pitch, wherein the ball acts in a direction opposite to the pitcher, ie, it swings from left to right for a right handed pitcher and so on.

This visual has been used in MAD magazine, Sad Sack, and several comics of the Comedy Genre.

Two word phrase

ID