Question 426: Weight a second

THis really needs no explanation, just fill in the blank in the last image. Something we all leartn before we knew what it was. This is aongst the most famous derivations in the world, as is the answer.

Question 425: Post Graduate

CONNECT

Question 424: Goddy's Gift; (HP)

In one of the myths surrounding Alexander the Great, Alexander's army was attacked by ____X_____ as they marched east, with a great number of soldiers killed. Rather than retreating, Alexander, admiring the creatures' strength and nobility, trapped four of them with meat lures fixed to his chariot. The ____X____ took the lures and were caught, then took flight, drawing the chariot high into the air, where Alexander saw the whole of Greece and Europe stretched out beneath him in the sun. Eventually they flew so high that the sun started to burn the ____X______s' wings, and they landed again. Since the establishment of this mythology, _____X_____have often been depicted as chariot- or carriage-pulling beasts for especially noble or powerful individuals.

However, in 1997, this word ( the creature's name) has entered the normal parlance (refer to the name of the post)
Question:
1) Id this creature.
2) Explain its connection to the picture

Question 423: Kingstown.

Our first guest question, by SyntaXerror

Fill in the Blanks.

2 - annihilated by bombardments during the second world war

2 - razed down and supplanted by 2 highways.

1 - Rebuilt in the 1930's.

The remaining ones are original, from __X___'s time.

Currently there are 5 in _____Y_____.

Gimme the person X and the place Y.

To contribute, look up the CONTACT page.

Question 422: New age hippie?

THis picture denotes a spoof of a fairly well known painting. This painting has been modified in a style to make it akin to a term popularised in the 1980's, but soon faded away from the lexicon as did its resurgence in the 2000's, and the reason it is fading away remains the same.
The term itself has spawned off several of its own terms, popular in their own rights, and has entered the Oxford English dictionary, as well as the common man's lexicon.
What the term denotes, to quote a famous exponent of it, who's name is associated with a sport that was ironically, most popular in the 1980's, is "all that was vile in the 1980's".

Fairly obscure, but hopefully there are enough clues in the question as well as the picture

Question:
Id the term

Clue:
The term has 6 letters.
The person is Tony Hawk( who made the quote)

Question 421: It Had to be this way.

What does this map depict?
Carlisle and Newcastle shown here.

Question 420: Would Brett have Done That?

Logo.
Building.
Logo has name on it.
Building doesn't.
So, Identify the building, if possible,
But more importantly,

Explain the significance of the building.

Question 419: Pinky and the brain

Connect the following to a single theme

and provide an explanation for each picture.

Question 418; Beating round

This poem, published in richard poor's almanac ( a derivative of Franklin's poor richard's almanac no doubt) is a compendium, a compilation of what one would call comedy. In the past decade, we have heard these phrases individually, but the author took the liberty of compiling them into a poem

Question:
1 Id the person in question
2) The name of the poem(same as what has been blanked out)
3) The term it spawned

Question 417: Up up and away

THis describes the mechanism of what has been deemed as a miracle for mankind.

ID the blank

The mechanism of action of___X___ involves the protection of cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum. Nitric oxide (NO) in the corpus cavernosum of the _____ binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation (vasodilation) of the intimal cushions of the helicine arteries. This smooth muscle relaxation leads to vasodilation and increased inflow of blood into the spongy tissue, causing ________ . Robert F. Furchgott won the Nobel Prize in Physiology or Medicine in 1998 for his discovery and analysis of endothelium-derived relaxing factor or "EDRF", later identified with NO itself or a closely-related compound.